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Could exacerbate accumulation of conjugated bile salts during the liver and cause clinical indicators. If concomitant use is essential, check serum transaminases and bilirubin.
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NSAIDs may diminish the antihypertensive influence of ACE inhibitors. The system of such interactions is likely related to the flexibility of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
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aspirin decreases outcomes of candesartan by pharmacodynamic antagonism. Modify Therapy/Watch Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and so influence fluid homeostasis and could diminish antihypertensive outcome.
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aspirin, alteplase. Both improves toxicity of the other by anticoagulation. Use Warning/Monitor. The necessity for simultaneous use of reduced-dose aspirin and anticoagulant or antiplatelet agents are typical for individuals with cardiovascular disease; keep track of closely.
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